Summary
CabBCII-10 is a universal nanobody framework capable of accepting diverse CDRs without being destabilized (see Humanization can destabilize antibodies; (1)).
1.
Vincke C, Loris R, Saerens D, Martinez-Rodriguez S, Muyldermans S, Conrath K. General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold. Journal of Biological Chemistry. 2009;284(5):3273–84. Available from: https://doi.org/10.1074/jbc.m806889200