Summary
The effect of missense mutations on folding are greater than on binding. This is also true for energy couplings (the second-order effects of introducing two or more mutations at once; (1)). Those authors also cite Faure et al. “Mapping the energetic and allosteric landscapes of protein binding domains” 2022. and Weng et al “The energetic and allosteric landscape for KRAS inhibition” 2022
1.
Faure AJ, Martí-Aranda A, Hidalgo-Carcedo C, Beltran A, Schmiedel JM, Lehner B. The genetic architecture of protein stability. Nature. 2024;634(8035):995–1003. Available from: https://doi.org/10.1038/s41586-024-07966-0