Summary
Filtering metrics used for de novo minibinder design vary in target-specific usefulness. It is unclear whether this is a broader symptom of the degree to which specific targets are structurally enabled (1).
Figures
Figure from (1)
See also
- AlphaFold3 ipTM can distinguish between antibody binders and nonbinders
- Protein structure prediction and design confidence metrics do not correlate with binding affinity
- Structure prediction uncertainty metrics as energy functions
1.
Yao Z, Metts M, Huber AK, Li J, Kinjo T, Dieckhaus H, et al. Enhancing ML-based binder design with high-throughput screening: a comparison of mRNA and yeast display technologies. openRxiv; 2026. Available from: https://doi.org/10.64898/2026.02.12.705611