Quartz 4

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Binders

Created Sep 26, 2026Modified Sep 07, 2026

Designing non-antibody protein binders and cross-format binder workflows; antibody-only work goes under design/antibodies.

10 items with this tag.

Sep 25, 2026
Surface-complementary seeds expand the structural diversity of diffusion-designed protein binders
Aug 25, 2026
Ensembling structure prediction methods for filtering improves recovery
Aug 19, 2026
Confidence metrics are not general binding-affinity predictors
Jul 20, 2026
Experimentally successful miniprotein binders have higher predicted stability
Jul 17, 2026
Cell-free systems have higher expression rates for minibinders than cell-based systems
Jul 17, 2026
Effectiveness of filtering metrics for de novo minibinder design vary by target
- evidence/design-validation
- design/binders
Apr 21, 2026
Affinity maturation of de novo minibinders introduces mutations far from the active site
- design/binders
- design/directed-evolution
Apr 21, 2026
Monomeric AF2 is better able to distinguish positive and negative PPIs than AF2-multimer
Apr 21, 2026
Partial diffusion of de novo designed binders and VHHs improves refoldability and designability scores
Apr 21, 2026
ProteinMPNN-derived inverse folding methods underdesign aromatic residues
- design/inverse-folding
- design/binders

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