Summary
Epistasis in antibodies during affinity maturation can be driven by conformational rearrangements in CDRs (1). In this case, the mechanism by which some mutations are not uniformly beneficial is due to conformational rigidification.
Figures
Figures from (1)
See also
- Conformational dynamics facilitate the emergence of catalytic activity in non-enzyme ligand-binding proteins
- Second-shell mutations can yield positive epistasis
1.
Tharp CR, Catalano C, Khalifeh A, Ghaffari-Kashani S, Huang R, Kang G, et al. Biophysical trade-offs in antibody evolution are resolved by conformation-mediated epistasis. openRxiv; 2026. Available from: https://doi.org/10.64898/2026.03.12.711465