Summary
Epistasis can arise from changes in which step in the catalytic cycle is rate limiting (1)
See also
1.
Fröhlich C, Bunzel HA, Buda K, Mulholland AJ, van der Kamp MW, Johnsen PJ, et al. Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase. Nature Catalysis. 2024;7(5):499–509. Available from: https://doi.org/10.1038/s41929-024-01117-4