Summary
The equilibrium dynamics of Fold-switching proteins change over time. (1) show used Ancestral sequence reconstruction on XCL1 and (NMR) that the relative populations of two states change as the sequence changes.
Figures
Ref (1)
1.
Dishman AF, Tyler RC, Fox JC, Kleist AB, Prehoda KE, Babu MM, et al. Evolution of fold switching in a metamorphic protein. Science. 2021;371(6524):86–90. Available from: https://doi.org/10.1126/science.abd8700