Summary
A fitness landscape’s navigability during directed evolution is correlated with its kurtosis (how tailed it is) and the centeredness of its maximum (1).
Figures
Ref (1)
1.
Li F-Z, Yang J, Johnston KE, Gürsoy E, Yue Y, Arnold FH. Evaluation of machine learning-assisted directed evolution across diverse combinatorial landscapes. Cell Systems. 2025;16(9):101387. Available from: https://doi.org/10.1016/j.cels.2025.101387