Summary
Insertion mutations and deletion mutations are better tolerated at protein termini (1). Could be why intrinsically disordered regions are typically found at the termini of proteins.
Figures
Ref (1)
1.
Topolska M, Beltran A, Lehner B. Deep indel mutagenesis reveals the impact of amino acid insertions and deletions on protein stability and function. Nature Communications. 2025;16(1). Available from: https://doi.org/10.1038/s41467-025-57510-5