Summary
Indels more detrimental to stability than missense mutations (1).
See also
- Indels better tolerated at termini
- Insertions more tolerated than deletions
- Missense mutation effects are predictive of effects of indels
- Single deletion mutations are better tolerated than larger (2-3 residue) deletions
1.
Topolska M, Beltran A, Lehner B. Deep indel mutagenesis reveals the impact of amino acid insertions and deletions on protein stability and function. Nature Communications. 2025;16(1). Available from: https://doi.org/10.1038/s41467-025-57510-5