Summary
Individual antibody paratopes can recognize to and bind to multiple epitopes(1). This was verified when designing synthetic antigens against nanobodies with experimentally determined structures.
1.
Altieri N, Harman JL, Noble D, Murakowska N, Eng A, McGowan KL, et al. The Synthetic Epitope Atlas: High-Throughput Design and Validation of De Novo Antibody-Antigen Complexes. bioRxiv. 2026; Available from: https://www.biorxiv.org/content/early/2026/04/19/2026.04.17.719295