Summary
Light chains determine the autospecificity of antibodies (1). Lambda light chains were found to be more effective at “silencing” autoreactivity. ML models trained on just light chains were as effective as those trained on full antibody sequences at predicting polyreactivity (2).
Figures
Ref (1)
See also
1.
Wardemann H, Hammersen J, Nussenzweig MC. Human Autoantibody Silencing by Immunoglobulin Light Chains. The Journal of Experimental Medicine. 2004;200(2):191–9. Available from: https://doi.org/10.1084/jem.20040818
2.
Jagota M, Hsu C, Mazumder T, Sung K, DeWitt WS, Listgarten J, et al. Learning antibody sequence constraints from allelic inclusion. Cell Systems. 2025;16(9):101368. Available from: https://doi.org/10.1016/j.cels.2025.101368