Summary
Antibodies from naive B cells are more polyreactive than those from memory B cells or those that have been clinically approved (1).
Figures
Figure 1A from (1)
See also
- Conformational entropy in antibodies is inversely proportional to antigen affinity
- Dynamics and specificity are inversely related
1.
Shehata L, Maurer DP, Wec AZ, Lilov A, Champney E, Sun T, et al. Affinity Maturation Enhances Antibody Specificity but Compromises Conformational Stability. Cell Reports. 2019;28(13):3300-3308.e4. Available from: https://doi.org/10.1016/j.celrep.2019.08.056