MPNN-like design profiles may be the source of high thermostability

Summary

MPNN-like design profiles may be the source of high thermostabilityProteinMPNN-like sequence design profiles may be the source of high thermostability (1). This was observed in the Proteina-Complexa paper, which sampled sequences in two “modes”, one low-temperature (yielding sequence profiles similar to ProteinMPNN outputs) and one high-temperature (yield sequences with UniProt-like residue propensities). The former were more thermostable than the latter.

Figures

Ref (1)

See also

• Glutamate- and lysine-rich designs can fail due to expression failures resulting from adenosine-rich sequences

1.

Didi K, Zhang Z, Zhou G, Reidenbach D, Cao Z, Cha S, et al. Scaling Atomistic Protein Binder Design with Generative Pretraining and Test-Time Compute. 2026; Available from: https://arxiv.org/abs/2603.27950