Summary
Multiple nanobodies can bind their targets simultaneously and can bind in a synergistic manner. (1) demonstrated this with the SARS-CoV-2 Spike protein.
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Ref (1)
1.
Mast FD, Fridy PC, Ketaren NE, Wang J, Jacobs EY, Olivier JP, et al. Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape. eLife. 2021;10. Available from: https://doi.org/10.7554/elife.73027