Summary
Nanobodies designed de novo from sequence (e.g., from PLMs) tend to be more flexible than those designed from structure, or those occurring naturally (1).
1.
Löhr T, Sormanni P, Vendruscolo M. Conformational Entropy as a Potential Liability of Computationally Designed Antibodies. Biomolecules. 2022;12(5):718. Available from: https://doi.org/10.3390/biom12050718