Summary
PLM embeddings can capture whether antibodies are engineered from those derived from humans (1). In contrast, (2) claims that engineered antibodies occupy a subspace of the broader diversity of natural antibodies when using ESM-1v.
Figures
Ref (1)
See also
- PLMs cluster antibodies from the same repertoire by V gene and maturation status
- CDR representations segregate into distinct clusters
1.
Singh R, Im C, Qiu Y, Mackness B, Gupta A, Joren T, et al. Learning the language of antibody hypervariability. Proceedings of the National Academy of Sciences. 2024;122(1). Available from: https://doi.org/10.1073/pnas.2418918121
2.
Bashour H, Smorodina E, Pariset M, Zhong J, Akbar R, Chernigovskaya M, et al. Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability. Communications Biology. 2024;7(1). Available from: https://doi.org/10.1038/s42003-024-06561-3