Summary
PPI interfaces are highly degenerate (1,2). Interactions can be deconstructed to pairs of nine residues and were found about 10,000 unique inter-fragment interactions.
Related
1.
Su Z, Dhusia K, Wu Y. Encoding the space of protein-protein binding interfaces by artificial intelligence. Computational Biology and Chemistry. 2024;110:108080. Available from: https://doi.org/10.1016/j.compbiolchem.2024.108080
2.
Verma R, Pandit SB. Unraveling the structural landscape of intra-chain domain interfaces: Implication in the evolution of domain-domain interactions. PLOS ONE. 2019;14(8):e0220336. Available from: https://doi.org/10.1371/journal.pone.0220336