OmegaFold is a protein structure prediction method from Wu et al. (1) that uses a custom-designed masked PLM to predict structures without Multiple sequence alignments. Similar to ESMFold. Found to model CDRH3 loops more accurately than AlphaFold2 (2).
1.
Wu R, Ding F, Wang R, Shen R, Zhang X, Luo S, et al. High-resolution de novo structure prediction from primary sequence. openRxiv; 2022. Available from: https://doi.org/10.1101/2022.07.21.500999
2.
Singh R, Im C, Qiu Y, Mackness B, Gupta A, Joren T, et al. Learning the language of antibody hypervariability. Proceedings of the National Academy of Sciences. 2024;122(1). Available from: https://doi.org/10.1073/pnas.2418918121