Summary
CDRH3 is not amenable to sequence clustering (Guloglu and (1)). This is unlike other CDRs, which form conformational clusters (2).
1.
Guloglu B, Deane CM. Specific attributes of the VL domain influence both the structure and structural variability of CDR-H3 through steric effects. Frontiers in Immunology. 2023;14. Available from: https://doi.org/10.3389/fimmu.2023.1223802
2.
Kelow S, Faezov B, Xu Q, Parker M, Adolf-Bryfogle J, Dunbrack RL. A penultimate classification of canonical antibody CDR conformations. openRxiv; 2022. Available from: https://doi.org/10.1101/2022.10.12.511988