Summary
Loop prediction precision for CDRs can be improved using length-independent structural hierarchical clustering (1). This allows “a much larger part of the antibody space” to be structurally defined. Sequence similarity within clusters of different sizes is attributed to shared V-genes.
Details
Length-independent conformational clustering was carried out using the Dynamic time warping algorithm. No multi-length clusters were found in CDRH1, CDRH2, or CDRH3.
Figures
Ref (1)
See also
1.
Nowak J, Baker T, Georges G, Kelm S, Klostermann S, Shi J, et al. Length-independent structural similarities enrich the antibody CDR canonical class model. mAbs. 2016;8(4):751–60. Available from: https://doi.org/10.1080/19420862.2016.1158370