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Structural datasets overrepresent a small number of epitopes

Structural datasets overrepresent a small number of epitopes

Created Aug 25, 2026Modified Aug 25, 2026

  • evidence/datasets
  • antibodies/nanobodies

Summary

Nonredundant nanobody-antigen structural datasets overrepresent a small number of epitopes (1).

Figures

Figure from (1)

See also

  • Nanobodies and Abs target different epitopes but with similar accessibility and number of contacts
  • Most nanobodies do not bind using all three CDRs
1.
Medved T, Lah J, Miličić G, Hadži S. AVIDbase: A biologically accurate structural dataset of nanobody-antigen complexes. Protein Science. 2026;35(9):e70773. Available from: https://doi.org/10.1002/pro.70773

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