Summary
ddG predictions calculated from AlphaFold2 structures using variant effect prediction methods are equally accurate as those derived from experimental structures (1).
See also
- High-accuracy computational models might not always be effective for ligand docking
- Training inverse folding and diffusion models exclusively on predicted protein structures worsens performance due to how locally perfect they are
1.
Diaz DJ, Gong C, Ouyang-Zhang J, Loy JM, Wells J, Yang D, et al. Stability Oracle: A Structure-Based Graph-Transformer for Identifying Stabilizing Mutations. openRxiv; 2023. Available from: https://doi.org/10.1101/2023.05.15.540857