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pLDDT correlates with number of homologous sequences provided during runtime

pLDDT correlates with number of homologous sequences provided during runtime

Created Aug 06, 2024Modified Apr 21, 2026

  • structure-prediction/metrics
  • plddt

Summary

pLDDT of structures predicted by AlphaFold2 correlate with the number of sequences provided for inference during runtime (1).

Figures

Ref (1)

See also

  • PLMs are biased by uneven distribution of sequence data in datasets such as UniRef and UniProt
1.
Avasthi P, York R. The known protein universe is phylogenetically biased. 2024; Available from: https://thestacks.org/publications/result-protein-universe-phylogenetic-bias

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Backlinks

  • Confidence metrics for diffusion-based structure prediction methods can be improved with minimal changes to conditioning representations
  • Structure prediction uncertainty metrics as energy functions

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