AlphaFlow and ESMFlow are versions of AlphaFold2 and ESMFold that are fine-tuned on MD simulations to model conformational heterogeneity using normalizing flows (1).
1.
Jing B, Berger B, Jaakkola T. AlphaFold Meets Flow Matching for Generating Protein Ensembles. In: GenBio@NeurIPS2023. 2023. Available from: https://openreview.net/forum?id=yQcebEgQfH