Summary
Aromatic and polar residues make up a disproportionate number of antigen epitopes, while apolar residues are underrepresented(1). This was derived from several hundred thousand predicted antibody structures from Alphafold3.
Figures
Ref (1)
See also
1.
Sang Z, Xiang Y, Huang W, Sargunas PR, Kim YJ (Jeffery), Feng Z, et al. Repertoire-scale antibody structural prediction informs therapeutic design. Science Advances. 2026 Apr;12(17). Available from: http://dx.doi.org/10.1126/sciadv.aef7163