Summary
CDR3 loops encode specificity while CDRs 1 and 2 encode cross-reactivity (1).
See also
1.
Xu JL, Davis MM. Diversity in the CDR3 Region of VH Is Sufficient for Most Antibody Specificities. Immunity. 2000;13(1):37–45. Available from: https://doi.org/10.1016/s1074-7613(00)00006-6