Summary
Conformational rigidity in CDRH3 reduces polyreactivity (1).
See also
- Conformational entropy in antibodies is inversely proportional to antigen affinity
- CDR3 loops encode specificity while CDR1 and CDR2 encode cross-reactivity
1.
Fernández-Quintero ML, Loeffler JR, Bacher LM, Waibl F, Seidler CA, Liedl KR. Local and Global Rigidification Upon Antibody Affinity Maturation. Frontiers in Molecular Biosciences. 2020;7. Available from: https://doi.org/10.3389/fmolb.2020.00182