Summary
CDRH3 is shorter in mice than human antibodies. It is also shorter in therapeutic antibodies, even those of human origin (1).
Figures
From (1)
See also
- Nanobody CDRH3 loops are longer but more compact
- Longer CDRH3 correlates with higher polyspecificity and hydrophobicity
1.
Raybould MIJ, Marks C, Krawczyk K, Taddese B, Nowak J, Lewis AP, et al. Five computational developability guidelines for therapeutic antibody profiling. Proceedings of the National Academy of Sciences. 2019;116(10):4025–30. Available from: https://doi.org/10.1073/pnas.1810576116