Summary
The CDRH3 loops of nanobodies are 3-4 residues longer on average, but more compact, than those of antibodies ((1), Bahrami (2)).
Figures
Ref (1)
See also
- Loops from one V-region chain affect the conformations and dynamics of loops in the other chain
- Inclusion of adjacent loops can improve CDRH3 structural modeling
1.
Gordon GL, Capel HL, Guloglu B, Richardson E, Stafford RL, Deane CM. A comparison of the binding sites of antibodies and single-domain antibodies. Frontiers in Immunology. 2023;14. Available from: https://doi.org/10.3389/fimmu.2023.1231623
2.
Bahrami Dizicheh Z, Chen I-L, Koenig P. VHH CDR-H3 conformation is determined by VH germline usage. Communications Biology. 2023;6(1). Available from: https://doi.org/10.1038/s42003-023-05241-y