Summary
Cytokines can be added to antibody CDRs while maintaining correct folding of both components (1). Here, a monomerized IL-10 cytokine was added to the CDRL1 of Palivizumab, although all six were tested.
1.
DiDonato M, Simpson CT, Vo T, Knuth M, Geierstanger B, Jamontt J, et al. A novel interleukin-10 antibody graft to treat inflammatory bowel disease. Structure. 2025;33(3):475-488.e7. Available from: https://doi.org/10.1016/j.str.2024.12.010