Summary
A large number of insertion mutations in one protein of the study were associated with gain of function (tighter ligand binding, Y-axis below; (1)). Note that this was not true of the other protein.
Figures
Ref (1)
See also
- Half of pathogenic mutations in intrinsically disordered regions improve binding to partners, or create new binding partners
- Protein stability, expression, and resistance to proteolysis are correlated
1.
Topolska M, Beltran A, Lehner B. Deep indel mutagenesis reveals the impact of amino acid insertions and deletions on protein stability and function. Nature Communications. 2025;16(1). Available from: https://doi.org/10.1038/s41467-025-57510-5