Summary
Inverse folding models like ProteinMPNN can zero-shot predict expression changes arising from mutations in CDRs when the ground truth experimental structure is available(1). This suggests that destabilization of antibodies via mutations in CDRs may be driving poor expression.
Figures
Ref[@chun2026
1.
Chun C, Sohn B-K, Ki H, Jo JH, An H-T, Park J, et al. Landscape-scale navigation unlocks antibody CDR structural logic for AI-guided rescue and therapeutic optimization. 2026 Apr; Available from: http://dx.doi.org/10.64898/2026.04.21.719857