Summary
Including adjacent CDRs can improve modeling of CDRH3 when modeling antibodies (Guloglu and (1)).
See also
- Loops from one V-region chain affect the conformations and dynamics of loops in the other chain
- Light chain coherence
- Deep learning methods produce different CDRH3 conformers
1.
Guloglu B, Deane CM. Specific attributes of the VL domain influence both the structure and structural variability of CDR-H3 through steric effects. Frontiers in Immunology. 2023;14. Available from: https://doi.org/10.3389/fimmu.2023.1223802