Quartz 4

Home

❯

notes

❯

Somatic hypermutation correlates with lower hydrophobicity

Somatic hypermutation correlates with lower hydrophobicity

Created Feb 01, 2025Modified Apr 21, 2026

  • affinity-maturation
  • antibody-developability/hydrophobicity

Summary

Somatic hypermutation of antibodies correlates with lower hydrophobicity (1).

Figures

Figure 2B from (1)

See also

  • Somatic hypermutation correlates with lower polyreactivity
1.
Shehata L, Maurer DP, Wec AZ, Lilov A, Champney E, Sun T, et al. Affinity Maturation Enhances Antibody Specificity but Compromises Conformational Stability. Cell Reports. 2019;28(13):3300-3308.e4. Available from: https://doi.org/10.1016/j.celrep.2019.08.056

Graph View

Created with Quartz v4.5.2 © 2026

  • GitHub
  • Discord Community