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Tag: thermostability/mutations
7 items with this tag.
Apr 21, 2026
Half of all disease-causing missense variants due to disruption of protein stability
thermostability/mutations
Apr 21, 2026
Most mutations with no effect on stability are found near the surface of proteins
thermostability/mutations
Apr 21, 2026
Recessive genetic diseases more likely to be caused by protein destabilization than dominant genetic diseases
thermostability/mutations
Apr 21, 2026
The majority of missense mutations are destabilizing
thermostability/mutations
Apr 21, 2026
Alpha-helices are more tolerant of mutations than beta-sheets
thermostability/mutations
Apr 21, 2026
Insertions and deletions are more detrimental to stability than substitutions
thermostability/mutations
Apr 21, 2026
Mutations that give rise to new functions are not more destabilizing than mutations in general
thermostability/mutations