Summary
Antigen context improves CDRH3 structure prediction (1). This is pronounced in longer loops (17+ residues).
Figures
Ref (1)
See also
- Correct CDRH3 prediction is necessary but insufficient for correct Ab-Ag docking
- Inclusion of adjacent loops can improve CDRH3 structural modeling
1.
Hitawala FN, Gray JJ. What does AlphaFold3 learn about antigen and nanobody docking, and what remains unsolved?. openRxiv; 2024. Available from: https://doi.org/10.1101/2024.09.21.614257