Summary
Gating template use during CDR design increases success rates. A mechanism that gates templates during antibody CDR design improves refoldability and amino acid recovery, and the gate was trained on synthetic junk sequences (1).
Figures
Ref (1)
See also
- Template CDR retrieval using embeddings
- Antigen context improves CDRH3 structure prediction
- Correct CDRH3 prediction is necessary but insufficient for correct Ab-Ag docking
1.
Liu P, Yan C, Pan M, Liu X, Huang S, Wu Z, et al. Robust Conditional Diffusion with Noisy Templates for Antibody Sequence-Structure Design. openRxiv; 2026. Available from: https://doi.org/10.64898/2026.06.18.733127