Quartz 4

❯

Single chain variable fragments

Created Apr 10, 2026Modified Apr 21, 2026

Single-chain variable fragments (abbreviated as scFv), consist exclusively of the variable regions of the heavy and/or light chains of antibodies.

Graph View

Backlinks

Cytokines
Gibbs sampling is less effective than simpler algorithms for sequence design using PSSMs
Heavy and light chains of de novo designed antibodies with the same framework and binding mode can be exchanged
ML optimized Ab libraries have more mutations than PSSM libraries
Nanobodies are more easily expressed in bacteria and yeast than IgG antibodies
Net charge of CDRs strongly predicts nonspecific binding
Simultaneous design of scFv loops predicted to lead to more fit sequences

GitHub
Discord Community

Quartz 4

Explorer

Single chain variable fragments

Graph View

Backlinks