Up to 22 percent of antigen binding residues are outside CDRs

Summary

Up to 22% of residues in antibodies that bind to antigens are not in the CDRs (1).

See also

• CDRH3 conformation is affected by interdomain orientation
• Nanobody framework residues more likely to be part of paratope than those of antibodies

1.

Fernández-Quintero ML, Vangone A, Loeffler JR, Seidler CA, Georges G, Liedl KR. Paratope states in solution improve structure prediction and docking. Structure. 2022;30(3):430-440.e3. Available from: https://doi.org/10.1016/j.str.2021.11.001