Quartz 4

❯

❯

❯

Function

Created Sep 26, 2026Modified Sep 07, 2026

Predicting functional annotations, catalytic activity, and enzyme specificity.

10 items with this tag.

May 10, 2026
Model type less important than data quantity when predicting catalytic properties of protein sequences
- prediction/function
- evidence/datasets
Apr 21, 2026
Closely-related enzymes can have disparate catalytic efficiencies that weakly correlate with sequence similarity
- biophysics/catalysis
- prediction/function
Apr 21, 2026
Contrastive learning improves segregation of functional clusters
Apr 21, 2026
Distance between PLM representations of two proteins correlates with functional dissimilarity
- model-analysis/representation-geometry
- prediction/function
Apr 21, 2026
Function prediction
- prediction/function
Apr 21, 2026
Most ML quality metrics cannot effectively predict enzyme activity after controlling for similarity to native
Apr 21, 2026
Protein language model embeddings are more predictive of homology than catalytic efficiency
Apr 21, 2026
Structure-based methods outperform sequence-based methods at zero-shot prediction of binding, whereas the reverse is true for zero-shot prediction of enzymatic activity
- prediction/binding
- prediction/function
Apr 21, 2026
The activity profiles of ancestrally reconstructed enzymes are more difficult to predict than extant or ML-generated enzymes
Apr 21, 2026
Incorporating ancestral sequences during PLM training improves performance in downstream tasks

Created with Quartz v4.5.2 © 2026

GitHub
Discord Community