Selection, mutation effects, ancestry, and homology across natural and engineered proteins.
Selection, mutation effects, ancestry, and homology across natural and engineered proteins.
Ancestral reconstruction, consensus sequences, historical inference, and their uses in engineering.
14 items with this tag.
Homology detection, sequence and structural alignment, remote similarity, and conservation across related proteins.
21 items with this tag.
Biological effects of substitutions and indels, fitness landscapes, epistasis, and accessible evolutionary paths. Prediction algorithms go under prediction/variant-effects.
47 items with this tag.
Natural selection, evolutionary constraints, adaptation, evolvability, and the natural distribution of sequence and fold space.
44 items with this tag.